Please use this identifier to cite or link to this item:
http://ir.lib.seu.ac.lk/handle/123456789/3234| Title: | New monoterpenoid by biotransformation of thymoquinone using Aspergillus niger |
| Authors: | Yasin Mohammad, Mohammad Shakya, Ashok Al-Bakain, Ramia Haroon, M.H. Choudhary, M. Iqbal |
| Keywords: | Thymoquinone Aspergillus niger Fungal transformation Oxidation Reduction Antioxidant activity |
| Issue Date: | 12-Jun-2018 |
| Publisher: | Elsevier Publication |
| Citation: | Bioorganic Chemistry, 80: 212–215. |
| Abstract: | Microbial transformation of thymoquinone (5-isopropyl-2-methyl-cyclohexa-2,5-diene-1,4-dione) (1) by suspended cell-cultures of the plant pathogenic fungus Aspergillus niger resulted in the production of three metabolites. These metabolites were identified as 5-isopropyl-2-methyloxepin-1-one (2), 3-hydroxy-5-isopropyl-2- methylcyclohexa-2,5-diene-1,4-dione (3), and 5-isopropyl-2-methylbenzene-1,4-diol (4) by different spectroscopic methods. Metabolite 2 was found to be a new compound. Compound 4 showed a potent antioxidant activity. |
| URI: | https://www.sciencedirect.com/science/article/abs/pii/S0045206818303092 |
| ISSN: | 0045-2068 |
| Appears in Collections: | Research Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 10.1016@j.bioorg.2018.06.019.pdf | 321.54 kB | Adobe PDF |  View/Open |
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